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| UWHC Lab Test Details | |
|---|---|
| Test Name | SSB Ab |
| Test Code(s) | HCSSB, SSB |
| CPT Code(s) | 86235 |
| Methodology | Enzyme Immunoassay |
| Clinical Information | Antibodies to extractable nuclear antigens (SSA, SSB, RNP, Sm) are found in many connective tissue diseases including SLE (SSA, SSB, RNP, SM), mixed connective tissue disease (high titer RNP), Sjogren's syndrome (SSA, SSB) and scleroderma (SSA, RNP). Sm is very specific for SLE, but not sensitive (30%). Mixed connective tissue disease is almost always (90%) associated with high titer RNP and is associated with antibodies to the 70kd protein by Western blot. SSA is found in approximately 70% of patients with Sjogren's syndrome, whereas SSB is found in 30% of patients. Scleroderma is typically associated with centromere or Scl-70 antibodies, but RNP and SSA are found in a small proportion of patients. |
| Testing Site | University Hospital |
| Days Performed | Mon-Fri, dayshift - day varies. |
| In-Lab Turnaround Time | 1 week. |
| Collection Requirements | |||||
|---|---|---|---|---|---|
| Specimen | Blood | ||||
| Collection Container |
| ||||
| Collection Volume | 3 mL | ||||
| Pediatric Collection Volume | 1 mL | ||||
| Specimen Processing Requirements | |||||||
|---|---|---|---|---|---|---|---|
| Stability |
| ||||||
| Sample Analyzed | Serum | ||||||
| Testing Volume | 1 mL | ||||||
| Pediatric Testing Volume | 0.3 mL | ||||||
| Specimen Processing | Centrifuge. Transfer cell-free serum to plastic vial. Refrigerate. | ||||||
| Outreach Specimen Processing | Centrifuge. If a complete barrier has not formed, transfer cell-free serum to plastic vial. Refrigerate. | ||||||
| Specimen Transport | Transport specimen to laboratory. Transport with coolant pack if coming from clinic location. | ||||||
| Unacceptable Criteria | Hemolyzed, grossly lipemic/turbid and icteric specimens are not acceptable. | ||||||
| Interpretation | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Reference Interval | Normal SSB (0 days and up): < 20
| ||||||||||
